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/>　　機械通氣這種手段為臨床醫(yī)學(xué)研究中*的生命支持手段，為進行動物實驗和動物疾病治療提供了時間，極大的提高了一些長時間性實驗或者開胸等呼吸衰竭實驗的成功率。<br />　　關(guān)于呼吸機歷史還蠻悠久的，這里我們簡單回顧下：<br />　　早在羅馬帝國時代，呼吸機就有一個雛形。1792年，當(dāng)時在慈善協(xié)會(Royal Humanne Society)的支持下，在人身上實施氣管切開、插管及風(fēng)箱式正壓通氣技術(shù)，用于溺水患者的復(fù)蘇，在當(dāng)時歐洲被廣泛接受。后面因為會產(chǎn)生致命性的氣胸被終止。到了20世紀(jì)，由Driker-Shaw在1928年研制成的“鐵肺”（iron lung），使當(dāng)時脊髓灰質(zhì)炎的死亡率大大降低。開始了一種負壓通氣的模式。<br />　　而現(xiàn)今我們在市面上看到不同工作方式的的小動物呼吸機。那么他們之間又是怎樣區(qū)分的呢?<br />　　1、依據(jù)不同的吸氣控制方式，可以將呼吸機分為壓力控制型呼吸機和容量控制型呼吸機，在臨床呼吸機領(lǐng)域，壓力控制更主流一些。在但動物實驗領(lǐng)域，相當(dāng)多的用戶習(xí)慣設(shè)置潮氣量進行容積控制。<br />　　2、依據(jù)呼吸機的結(jié)構(gòu)原理，可分為活塞式呼吸機和電磁閥式呼吸機。一般活塞式呼吸機使用容積控制，而電磁閥式呼吸機即可以進行容控制，也可以進行壓力控制。<br />　　3、依據(jù)調(diào)控方式不同，可分為電動電控型和氣動電控型呼吸機。<br />　　因為具有不同的呼吸機，其實他們給動物的通氣方式也是不同的，根據(jù)通氣方式不同，我們可以將通氣方式分為：<br />　　控制模式（CV）：呼吸機*替代實驗動物的呼吸，其呼吸頻率，潮氣量均由呼吸機控制，屬于*的呼吸支持。適用于自主呼吸消失或很微弱的情況，比較典型的應(yīng)用，就是動物的開胸手術(shù)實驗。根據(jù)控制參數(shù)的不同，控制通氣又可以分為容量控制通氣(VCV）和壓力控制通氣(PCV)。容量控制通氣(VCV）是呼吸機按預(yù)置的潮氣量、呼吸頻率、呼吸比等參數(shù)完成通氣。壓力控制通氣(PCV)則是呼吸機按照預(yù)置的頻率、呼吸比、吸氣壓力工作。<br />　　輔助通氣（AV）: 呼吸機的送氣是通過呼吸機檢測實驗動物的氣道壓的降低來觸發(fā)。輔助通氣是一種與臨床應(yīng)用類似的呼吸方式，動物的輔助通氣一般可以通過設(shè)置壓力觸發(fā)、人工觸發(fā)或定時觸發(fā)等方式啟動。對于小動物呼吸機而言，輔助通氣(AV）是一種較的呼吸模式，僅少量小動物呼吸機具體此功能。<br />　　嘆氣模式(sigh): 是一種在常規(guī)呼吸通氣條件下，隔一段時間進行一次深呼吸的通氣方式。通常實驗動物在長期使用控制通氣，尤其是容量控制通氣條件下，某些邊緣肺泡會膨脹不全，肺部功能會逐步減弱，加入定時或手工嘆氣，可防止肺部萎陷不張，改善氣體交換性能。 </div> <div id="rplnt57" class="art-next"> <dl class="shangxia"> <dd>上一篇：<a href="/Article-1693482.html">竹園中為何可以應(yīng)用病蟲檢驗檢疫箱？</a> </dd> <dd>下一篇：<a href="/Article-1720983.html">標(biāo)本工具箱對病蟲害研究的積極意義</a> </dd> </dl> </div> </div> </div> </div> </div> </div> <div class="blbhp5t" id="clear"></div>  <footer> <div id="zvdthv7" class="footer"> <div id="vfjrxbn" class="footer1"> <div id="bphjlz5" class="w1200 clearfix"> <ul class="fl footer-nav 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